Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects.-论文-万方医学网

第一作者： Yufei,Han

第一单位： Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua RoadShenhe District, Shenyang, 110016, China.

作者： Yufei,Han ^[1] ; Desheng,Huang ^[2] ; Sicong,Xu ^[1] ; Lingling,Li ^[2] ; Ye,Tian ^[1] ; Shuo,Li ^[2] ; Cong,Chen ^[1] ; Yingxiu,Li ^[1] ; Yanping,Sun ^[2] ; Yunlei,Hou ^[1] ; Yongjun,Sun ^[2] ; Mingze,Qin ^[3] ; Ping,Gong ^[1] ; Zibin,Gao ^[4] ; Yanfang,Zhao ^[5]

作者单位： Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua RoadShenhe District, Shenyang, 110016, China. ^[1] State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Hebei University of Science and Technology, Shijiazhuang, China. ^[2] Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua RoadShenhe District, Shenyang, 110016, China; Chinese People's Liberation Army Logistics Support Force No.967 Hospital, Dalian 116021, PR China. ^[3] State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Hebei University of Science and Technology, Shijiazhuang, China. Electronic address: zbgao74@163.com. ^[4] Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua RoadShenhe District, Shenyang, 110016, China. Electronic address: yanfangzhao@126.com. ^[5]

医学主题词动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);苯并噻唑类(Benzothiazoles);角叉菜胶(Carrageenan);细胞存活(Cell Survival);剂量效应关系, 药物(Dose-Response Relationship, Drug);水肿(Edema);酶抑制剂(Enzyme Inhibitors);环氧水解酶类(Epoxide Hydrolases);Hep G2细胞(Hep G2 Cells);人类(Humans);炎症(Inflammation);配体(Ligands);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);微粒体, 肝(Microsomes, Liver);分子结构(Molecular Structure);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2020.113028

PMID 33248848

发布时间 2021-04-23

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Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects.

European journal of medicinal chemistry

相似文献

同项目论文

European journal of medicinal chemistry

相关期刊

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