An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease.

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作者： Geraldine,Kong ^[1] ; Susan,Ellul ^[2] ; Vinod K,Narayana ^[3] ; Komal,Kanojia ^[3] ; Harvey Tran Thai,Ha ^[1] ; Shanshan,Li ^[1] ; Thibault,Renoir ^[1] ; Kim-Anh Lê,Cao ^[4] ; Anthony J,Hannan ^[5]

作者单位： Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne Brain Centre, Parkville, VIC 3010, Australia. ^[1] Melbourne Integrative Genomics, School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. ^[2] Bio21 Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia; Metabolomics Australia, University of Melbourne, Parkville, VIC 3010, Australia. ^[3] Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne Brain Centre, Parkville, VIC 3010, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. ^[4] Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne Brain Centre, Parkville, VIC 3010, Australia; Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: anthony.hannan@florey.edu.au. ^[5]

关键词 Cognitive disorder Gut microbiome Huntington's disease Mouse model Movement disorder Neurodegeneration Polyglutamine Psychiatric disorder Short-chain fatty acids Tandem repeat disorder