Anti-inflammatory drug nanocrystals: state of art and regulatory perspective.

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第一作者： Luiza de O,Macedo

第一单位： University of Sao Paulo, Faculty of Pharmaceutical Sciences, 580, Prof. Lineu Prestes Avenue, - Bloco 15, Caixa-Postal 6608, CEP 05508-900, São Paulo - SP, Brazil. Electronic address: luiza-macedo@hotmail.com.

作者： Luiza de O,Macedo ^[1] ; Eduardo J,Barbosa ^[2] ; Raimar,Löbenberg ^[3] ; Nadia A,Bou-Chacra ^[4]

作者单位： University of Sao Paulo, Faculty of Pharmaceutical Sciences, 580, Prof. Lineu Prestes Avenue, - Bloco 15, Caixa-Postal 6608, CEP 05508-900, São Paulo - SP, Brazil. Electronic address: luiza-macedo@hotmail.com. ^[1] University of Sao Paulo, Faculty of Pharmaceutical Sciences, 580, Prof. Lineu Prestes Avenue, - Bloco 15, Caixa-Postal 6608, CEP 05508-900, São Paulo - SP, Brazil. Electronic address: edujbarbosa@hotmail.com. ^[2] University of Alberta, Faculty of Pharmacy and Pharmaceutical Sciences, Edmonton - AB, Canada T6G 2N8. Electronic address: raimar@ualberta.ca. ^[3] University of Sao Paulo, Faculty of Pharmaceutical Sciences, 580, Prof. Lineu Prestes Avenue, - Bloco 15, Caixa-Postal 6608, CEP 05508-900, São Paulo - SP, Brazil. Electronic address: chacra@usp.br. ^[4]

关键词 CQA nanocrystal NSAID delivery NSAID nanocrystals anti-inflammatory drug nanocrystal nanosuspensions targeting anti-inflammatory drugs

主题词消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);生物利用度(Biological Availability);环氧化酶2抑制剂(Cyclooxygenase 2 Inhibitors);纳米粒子(Nanoparticles);药用制剂(Pharmaceutical Preparations);溶解度(Solubility)

DOI 10.1016/j.ejps.2020.105654

PMID 33253884

发布时间 2021-06-21

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