换一批
换一批<i>N</i>-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.
第一作者：
Tao,Yang
第一单位：
State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
作者：
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);女(雌)性(Female);人类(Humans);异喹啉类(Isoquinolines);Janus激酶2(Janus Kinase 2);男(雄)性(Male);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);分子结构(Molecular Structure);骨髓增殖性疾病(Myeloproliferative Disorders);肿瘤(Neoplasms);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);嘧啶类(Pyrimidines);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);构效关系(Structure-Activity Relationship);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1021/acs.jmedchem.0c01488
PMID
33256400
发布时间
2021-02-16
- 浏览2
Journal of medicinal chemistry
14921-14936页
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