首页> Molecular imaging and biology> Quantification of SV2A Binding in Rodent Brain Using [<sup>18</sup>F]SynVesT-1 and PET Imaging.

Quantification of SV2A Binding in Rodent Brain Using [<sup>18</sup>F]SynVesT-1 and PET Imaging.

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第一作者： Pragalath,Sadasivam

第一单位： Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.

作者： Pragalath,Sadasivam ^[1] ; Xiaotian T,Fang ^[1] ; Takuya,Toyonaga ^[1] ; Supum,Lee ^[1] ; Yuping,Xu ^[1] ; Ming-Qiang,Zheng ^[1] ; Joshua,Spurrier ^[2] ; Yiyun,Huang ^[1] ; Stephen M,Strittmatter ^[2] ; Richard E,Carson ^[1] ; Zhengxin,Cai ^[3]

作者单位： Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA. ^[1] Program in Cellular Neuroscience, Neurodegeneration, and Repair, Departments of Cell Biology, Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, USA. ^[2] Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA. jason.cai@yale.edu. ^[3]

关键词 APP/PS1 Alzheimer’s disease PET SRTM SV2A Synapse density [18F]SynVesT-1

医学主题词阿尔茨海默病(Alzheimer Disease);动物(Animals);脑(Brain);脑干(Brain Stem);小脑(Cerebellum);药物设计(Drug Design);女(雌)性(Female);氟放射性同位素(Fluorine Radioisotopes);半数抑制浓度(Inhibitory Concentration 50);动力学(Kinetics);膜糖蛋白类(Membrane Glycoproteins);小鼠(Mice);神经组织蛋白质类(Nerve Tissue Proteins);正电子发射断层显像术(Positron-Emission Tomography);蛋白质结合(Protein Binding);吡啶类(Pyridines);吡咯烷类(Pyrrolidines);放射性药物(Radiopharmaceuticals)

DOI 10.1007/s11307-020-01567-9

PMID 33258040

发布时间 2023-02-23

基金项目

UL1 TR001863/TR/NCATS NIH HHS/United States K01 EB023312/EB/NIBIB NIH HHS/United States P30 AG066508/AG/NIA NIH HHS/United States R01 AG034924/AG/NIA NIH HHS/United States R01 AG058773/AG/NIA NIH HHS/United States RF1 AG070926/AG/NIA NIH HHS/United States R01 AG052560/AG/NIA NIH HHS/United States

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