首页> Pharmaceutical research> Application of a Two-Analyte Integrated Population Pharmacokinetic Model to Evaluate the Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Polatuzumab Vedotin in Patients with Non-Hodgkin Lymphoma.

Application of a Two-Analyte Integrated Population Pharmacokinetic Model to Evaluate the Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Polatuzumab Vedotin in Patients with Non-Hodgkin Lymphoma.

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第一作者： Dan,Lu

第一单位： Department of Clinical Pharmacology, Genentech, Inc, South San Francisco, California, USA. lu.dan@gene.com.;Genentech Research and Early Development, 1 DNA Way, MS46-3a, South San Francisco, California, 94080, USA. lu.dan@gene.com.

作者： Dan,Lu ^[1] ; Tong,Lu ^[2] ; Rong,Shi ^[2] ; Leonid,Gibiansky ^[3] ; Priya,Agarwal ^[2] ; Colby S,Shemesh ^[2] ; Randall C,Dere ^[4] ; Uzor,Ogbu ^[5] ; Jamie,Hirata ^[5] ; Pascal,Chanu ^[6] ; Sandhya,Girish ^[2] ; Jin Yan,Jin ^[2] ; Chunze,Li ^[2] ; Dale,Miles ^[2]

作者单位： Department of Clinical Pharmacology, Genentech, Inc, South San Francisco, California, USA. lu.dan@gene.com.;Genentech Research and Early Development, 1 DNA Way, MS46-3a, South San Francisco, California, 94080, USA. lu.dan@gene.com. ^[1] Department of Clinical Pharmacology, Genentech, Inc, South San Francisco, California, USA. ^[2] QuantPharm LLC, North Potomac, Maryland, USA. ^[3] Department of Bioanalytical Sciences, Genentech, Inc, South San Francisco, California, USA. ^[4] Product Development Oncology, Genentech, Inc, South San Francisco, California, USA. ^[5] Department of Clinical Pharmacology, Genentech, Inc/F. Hoffmann-La Roche Ltd, Lyon, France. ^[6]

关键词 antibody-drug conjugate integrated two-analyte non-Hodgkin lymphoma population pharmacokinetics