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Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.

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第一作者： Benjamin R,Pryce

第一单位： Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

作者： Benjamin R,Pryce ^[1] ; Cédrik,Labrèche ^[1] ; Dounia,Hamoudi ^[2] ; John,Abou-Hamad ^[1] ; Khalid N,Al-Zahrani ^[1] ; Jonathan J,Hodgins ^[3] ; Antoine,Boulanger-Piette ^[2] ; Sabrina,Bossé ^[2] ; Cindy,Balog-Alvarez ^[4] ; Jérôme,Frénette ^[5] ; Michele,Ardolino ^[3] ; Joe N,Kornegay ^[4] ; Luc A,Sabourin ^[6]

作者单位： Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. ^[1] Centre de Recherche du Centre Hospitalier Universitaire de Québec-Centre Hospitalier de L'Université Laval, Université Laval, Quebec City, Quebec, Canada. ^[2] Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. ^[3] Department of Veterinary Integrative Biosciences, Texas A&M University College of Veterinary Medicine & Biomedical Sciences, College Station, TX, USA. ^[4] Centre de Recherche du Centre Hospitalier Universitaire de Québec-Centre Hospitalier de L'Université Laval, Université Laval, Quebec City, Quebec, Canada; Département de Réadaptation, Faculté de Médecine, Université Laval, Quebec City, Quebec, Canada. ^[5] Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. Electronic address: lsabourin@ohri.ca. ^[6]

关键词 Gene knockout Muscular dystrophy Ste20-like kinase mdx

医学主题词动物(Animals);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);狗(Dogs);基因敲除技术(Gene Knockout Techniques);MAP激酶信号系统(MAP Kinase Signaling System);小鼠(Mice);小鼠, 近交mdx(Mice, Inbred mdx);小鼠, 基因敲除(Mice, Knockout);肌肉发育(Muscle Development);肌, 骨骼(Muscle, Skeletal);肌营养不良, 杜氏(Muscular Dystrophy, Duchenne);成肌细胞(Myoblasts);肌形成蛋白(Myogenin);转化生长因子β(Transforming Growth Factor beta);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1016/j.bbamcr.2020.118917

PMID 33259860

发布时间 2021-12-04

基金项目

CAPMC/ CIHR/Canada

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Biochimica et biophysica acta. Molecular cell research

2021年1868卷2期

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Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.

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Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.

Biochimica et biophysica acta. Molecular cell research

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Biochimica et biophysica acta. Molecular cell research

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