Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes.

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第一作者： Damien,Lagarde

第一单位： STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France.

作者： Damien,Lagarde ^[1] ; Yannick,Jeanson ^[1] ; Corinne,Barreau ^[1] ; Cedric,Moro ^[2] ; Lindsay,Peyriga ^[3] ; Edern,Cahoreau ^[3] ; Christophe,Guissard ^[1] ; Emmanuelle,Arnaud ^[1] ; Anne,Galinier ^[4] ; Anne-Karine,Bouzier-Sore ^[5] ; Luc,Pellerin ^[6] ; Edward T,Chouchani ^[7] ; Luc,Pénicaud ^[1] ; Isabelle,Ader ^[1] ; Jean-Charles,Portais ^[8] ; Louis,Casteilla ^[1] ; Audrey,Carrière ^[9]

作者单位： STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France. ^[1] Institute of Metabolic and Cardiovascular Diseases, INSERM UMR1048, Paul Sabatier University, Toulouse, France. ^[2] Toulouse Biotechnology Institute TBI - INSA de Toulouse INSA/CNRS 5504 - UMR INSA/INRA 7924, Toulouse, France; MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France. ^[3] STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France; Institut Fédératif de Biologie, CHU Purpan, Toulouse, France. ^[4] Université de Bordeaux, CNRS, CRMSB, UMR 5536, Bordeaux, France. ^[5] INSERM U1082, Université de Poitiers, Poitiers Cedex, France. ^[6] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. ^[7] STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France; Toulouse Biotechnology Institute TBI - INSA de Toulouse INSA/CNRS 5504 - UMR INSA/INRA 7924, Toulouse, France; MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France. ^[8] STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, Université Paul Sabatier, Toulouse, France; Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France. Electronic address: audrey.carriere-pazat@inserm.fr. ^[9]

关键词 beige adipocytes glycolysis lactate fluxes monocarboxylate transporters uncoupling protein 1

主题词动物(Animals);基因表达调控(Gene Expression Regulation);乳酸(Lactic Acid);男(雄)性(Male);间质干细胞(Mesenchymal Stem Cells);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);一元羧酸转运子(Monocarboxylic Acid Transporters);信号传导(Signal Transduction);协同转运子(Symporters);产热(Thermogenesis)

DOI 10.1074/jbc.RA120.016303

PMID 33268383

发布时间 2024-02-29

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The Journal of biological chemistry

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Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes.

The Journal of biological chemistry

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Lactate fluxes mediated by the monocarboxylate transporter-1 are key determinants of the metabolic activity of beige adipocytes.

The Journal of biological chemistry

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The Journal of biological chemistry

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