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Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis.

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作者单位: Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [1] Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA. [2] Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA. [3] Department of Pathology & Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [4] Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA. [5] Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA. [6] Department of Neurosciences, University of California San Diego, San Diego, CA, USA. [7] Department of Neurology, University of Iowa, Iowa City, IA, USA. [8] Forbes Norris ALS Center, California Pacific Medical Center, San Francisco, CA, USA. [9] Department of Neurology, Cleveland Clinic, Cleveland, OH, USA. [10] Department of Neurology, University of Texas Health Science Center, San Antonio, TX, USA. [11] Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. [12] Department of Neurology, Stanford University Medical Center, San Jose, CA, USA. [13] Department of Neurology, University of Minnesota Medical Center, Minneapolis, MN, USA. [14] Penn Image Computing Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [15] Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [16] Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [17] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. [18] Rare Diseases Clinical Research Network, National Institutes of Health, Bethesda, MD, USA. [19] The Howard Hughes Medical Institute, Chevy Chase, MS, USA. [20]
DOI 10.15252/emmm.202012595
PMID 33270986
发布时间 2023-11-10
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