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A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates.

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第一作者： Dennis,Wang

第一单位： Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom.;Department of Computer Science, University of Sheffield, Sheffield, United Kingdom.

作者： Dennis,Wang ^[1] ; James,Hensman ^[2] ; Ginte,Kutkaite ^[3] ; Tzen S,Toh ^[4] ; Ana,Galhoz ^[3] ; GDSC Screening Team ^[5] ; Jonathan R,Dry ^[6] ; Julio,Saez-Rodriguez ^[7] ; Mathew J,Garnett ^[5] ; Michael P,Menden ^[8] ; Frank,Dondelinger ^[9]

作者单位： Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom.;Department of Computer Science, University of Sheffield, Sheffield, United Kingdom. ^[1] PROWLER.io, Cambridge, United Kingdom. ^[2] Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Department of Biology, Ludwig-Maximilians University Munich, Martinsried, Germany. ^[3] The Medical School, University of Sheffield, Sheffield, United Kingdom. ^[4] Wellcome Sanger Institute, Cambridge, United Kingdom. ^[5] Research and Early Development, Oncology R&D, AstraZeneca, Boston, United States. ^[6] Institute of Computational Biomedicine,Faculty of Medicine,Heidelberg Universityand Heidelberg University Hospital, Bioquant, Heidelberg, Germany. ^[7] Institute of Computational Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.;Department of Biology, Ludwig-Maximilians University Munich, Martinsried, Germany.;German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. ^[8] Centre for Health Informatics, Computation and Statistics, Lancaster Medical School, Lancaster University, Lancaster, United Kingdom. ^[9]

关键词 biomarkers computational biology drug prediction human machine learning pharmacogenomics statistical inference systems biology uncertainty estimation

医学主题词抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);药物发现(Drug Discovery);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);统计学(主题)(Statistics as Topic)

DOI 10.7554/eLife.60352

PMID 33274713

发布时间 2025-05-30

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准确一般字义偏差语意偏离译文作用小提交