A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.

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第一作者： Maria,Kost-Alimova

第一单位： The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

作者： Maria,Kost-Alimova ^[1] ; Eriene-Heidi,Sidhom ^[2] ; Abhigyan,Satyam ^[3] ; Brian T,Chamberlain ^[1] ; Moran,Dvela-Levitt ^[2] ; Michelle,Melanson ^[1] ; Seth L,Alper ^[4] ; Jean,Santos ^[1] ; Juan,Gutierrez ^[1] ; Ayshwarya,Subramanian ^[1] ; Patrick J,Byrne ^[1] ; Elizabeth,Grinkevich ^[1] ; Estefanía,Reyes-Bricio ^[1] ; Choah,Kim ^[2] ; Abbe R,Clark ^[1] ; Andrew J B,Watts ^[2] ; Rebecca,Thompson ^[1] ; Jamie,Marshall ^[1] ; Juan Lorenzo,Pablo ^[1] ; Juliana,Coraor ^[2] ; Julie,Roignot ^[1] ; Katherine A,Vernon ^[2] ; Keith,Keller ^[2] ; Alissa,Campbell ^[2] ; Maheswarareddy,Emani ^[1] ; Matthew,Racette ^[1] ; Silvana,Bazua-Valenti ^[2] ; Valeria,Padovano ^[1] ; Astrid,Weins ^[5] ; Stephen P,McAdoo ^[6] ; Frederick W K,Tam ^[6] ; Luciene,Ronco ^[1] ; Florence,Wagner ^[1] ; George C,Tsokos ^[3] ; Jillian L,Shaw ^[1] ; Anna,Greka ^[2]

作者单位： The Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[1] The Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ^[2] Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. ^[3] The Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. ^[4] Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ^[5] Department of Immunology and Inflammation, Imperial College, Hammersmith Hospital, London, UK. ^[6]

关键词 ALI ARDS COVID-19 MUC1 SARS-CoV-2 acute lung injury acute respiratory distress syndrome drug repurposing fostamatinib

DOI 10.1016/j.xcrm.2020.100137

PMID 33294858

发布时间 2024-02-11

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Cell reports. Medicine

2020年1卷8期

100137页

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A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.

Cell reports. Medicine

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A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.

Cell reports. Medicine

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Cell reports. Medicine

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