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The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability.

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第一作者： Tian,Tian

第一单位： The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

作者： Tian,Tian ^[1] ; Min,Bu ^[1] ; Xu,Chen ^[1] ; Linli,Ding ^[1] ; Yulan,Yang ^[1] ; Jinhua,Han ^[1] ; Xin-Hua,Feng ^[1] ; Pinglong,Xu ^[1] ; Ting,Liu ^[2] ; Songmin,Ying ^[3] ; Yang,Lei ^[4] ; Qing,Li ^[4] ; Jun,Huang ^[5]

作者单位： The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China. ^[1] Department of Cell Biology and Department of General Surgery of Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China. ^[2] Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China. ^[3] Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. ^[4] The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: jhuang@zju.edu.cn. ^[5]

关键词 DNA topoisomerase DNA translocase SUMO E3 ligase SUMOylation genome instability replication fork restart replication fork reversal