Structural and Biochemical Features of <i>Eimeria tenella</i> Dihydroorotate Dehydrogenase, a Potential Drug Target.

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作者： Dan,Sato ^[1] ; Endah Dwi,Hartuti ^[2] ; Daniel Ken,Inaoka ^[3] ; Takaya,Sakura ^[4] ; Eri,Amalia ^[5] ; Madoka,Nagahama ^[3] ; Yukina,Yoshioka ^[4] ; Naotoshi,Tsuji ^[5] ; Tomoyoshi,Nozaki ^[1] ; Kiyoshi,Kita ^[1] ; Shigeharu,Harada ^[6] ; Makoto,Matsubayashi ^[5] ; Tomoo,Shiba ^[4]

作者单位： Department of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. ^[1] Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. ^[2] Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. ^[3] School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. ^[4] Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. ^[5] Department of Parasitology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan. ^[6] Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. ^[7] Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku Orai Kita, Izumisano, Osaka 598-8531, Japan. ^[8]

关键词 Eimeria tenella apicomplexa coccidium crystal structure dihydroorotate dehydrogenase electron transport chain inhibitor membrane protein mitochondria ubiquinone