Discovery of a Potent and Selective PI3Kδ Inhibitor (<i>S</i>)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4<i>H</i>-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models.

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作者： Manojkumar R,Shukla ^[1] ; Sukanya,Patra ^[1] ; Mahip,Verma ^[1] ; Gayathri,Sadasivam ^[1] ; Nirmal,Jana ^[1] ; Sachin J,Mahangare ^[1] ; Prashant,Vidhate ^[1] ; Dipak,Lagad ^[1] ; Anand,Tarage ^[1] ; Murthy,Cheemala ^[1] ; Chaitanya,Kulkarni ^[1] ; Shankar,Bhagwat ^[1] ; Vinod D,Chaudhari ^[1] ; Majid,Sayyed ^[1] ; Vipul,Pachpute ^[1] ; Ramesh,Phadtare ^[1] ; Gopal,Gole ^[1] ; Samiron,Phukan ^[1] ; Brahmam,Sunkara ^[1] ; Charudatt,Samant ^[1] ; Manisha,Shingare ^[1] ; Aditya,Naik ^[1] ; Sneha,Trivedi ^[1] ; Ajit Kumar,Marisetti ^[1] ; Madhusudhan,Reddy ^[1] ; Milind,Gholve ^[1] ; Nilesh,Mahajan ^[1] ; Sudeep,Sabde ^[1] ; Vinod,Patil ^[1] ; Dipak,Modi ^[1] ; Maneesh,Mehta ^[1] ; Prashant,Nigade ^[1] ; Kaustubh,Tamane ^[1] ; Swati,Tota ^[1] ; Hemant,Goyal ^[1] ; Harish,Volam ^[1] ; Shashikant,Pawar ^[1] ; Prajakta,Ahirrao ^[1] ; Lal,Dinchhana ^[1] ; Sadanand,Mallurwar ^[1] ; Atul,Akarte ^[1] ; Anand,Bokare ^[1] ; Rupesh,Kanhere ^[1] ; Neetinkumar,Reddy ^[1] ; Sarita,Koul ^[1] ; Manoj,Dandekar ^[1] ; Minakshi,Singh ^[1] ; Peter R,Bernstein ^[1] ; Lakshmi,Narasimham ^[1] ; Mandar,Bhonde ^[1] ; Jayasagar,Gundu ^[1] ; Rajan,Goel ^[1] ; Sanjeev,Kulkarni ^[1] ; Sharad,Sharma ^[1] ; Rajender Kumar,Kamboj ^[1] ; Venkata P,Palle ^[1]

作者单位： Novel Drug Discovery and Development, Lupin Ltd., Lupin Research Park, Survey No. 46 A/47A, Village Nande, Taluka Mulshi, Pune 412115, India. ^[1]