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首页> Microbial cell factories> Engineering Lactococcus lactis as a multi-stress tolerant biosynthetic chassis by deleting the prophage-related fragment.

Engineering Lactococcus lactis as a multi-stress tolerant biosynthetic chassis by deleting the prophage-related fragment.

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作者： Wanjin,Qiao ^[1] ; Yu,Qiao ^[2] ; Fulu,Liu ^[1] ; Yating,Zhang ^[1] ; Ran,Li ^[1] ; Zhenzhou,Wu ^[2] ; Haijin,Xu ^[3] ; Per Erik Joakim,Saris ^[4] ; Mingqiang,Qiao ^[2]

作者单位： Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, No.94 Weijin Road, Nankai District, Tianjin, 300071, China. ^[1] Department of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Helsinki, Finland. ^[2] State Key Laboratory of Medicinal Chemical Biology & Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin, China. ^[3] Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, No.94 Weijin Road, Nankai District, Tianjin, 300071, China. nkxuhaijin@163.com. ^[4] Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, No.94 Weijin Road, Nankai District, Tianjin, 300071, China. qiaomq@nankai.edu.cn. ^[5]

关键词 Genome editing Lactococcus lactis Multi-stress tolerance Nisin immunity Nisin yield Prophage-related fragment TMT quantitative proteomics

主题词抗菌药(Anti-Bacterial Agents);抗药性, 细菌(Drug Resistance, Bacterial);发酵(Fermentation);基因缺失(Gene Deletion);基因表达调控, 细菌(Gene Expression Regulation, Bacterial);基因组, 细菌(Genome, Bacterial);热温度(Hot Temperature);氢离子浓度(Hydrogen-Ion Concentration);乳酸(Lactic Acid);乳乳球菌(Lactococcus lactis);胞壁质酶(Muramidase);突变(Mutation);乳链球菌素(Nisin);原噬菌体(Prophages);蛋白质组(Proteome);应激, 生理学(Stress, Physiological)

DOI 10.1186/s12934-020-01487-x

PMID 33298073

发布时间 2021-09-01

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Microbial cell factories

Microbial cell factories

2020年19卷1期

225页

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