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Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining <i>In Vitro</i> Experiments with Systems Modeling.

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第一作者： Arthur J,Van De Vyver

第一单位： Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland. arthur.van_de_vyver@roche.com.;Saarland University, Department of Clinical Pharmacy, Saarbrücken, Germany.

作者： Arthur J,Van De Vyver ^[1] ; Tina,Weinzierl ^[2] ; Miro J,Eigenmann ^[3] ; Nicolas,Frances ^[3] ; Sylvia,Herter ^[2] ; Regula B,Buser ^[4] ; Jitka,Somandin ^[2] ; Sarah,Diggelmann ^[2] ; Florian,Limani ^[2] ; Thorsten,Lehr ^[5] ; Marina,Bacac ^[2] ; Antje-Christine,Walz ^[3]

作者单位： Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland. arthur.van_de_vyver@roche.com.;Saarland University, Department of Clinical Pharmacy, Saarbrücken, Germany. ^[1] Roche Pharma Research and Early Development, Cancer Immunotherapy Department 2, Roche Innovation Center, Zürich, Switzerland. ^[2] Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland. ^[3] Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center, Zürich, Switzerland. ^[4] Saarland University, Department of Clinical Pharmacy, Saarbrücken, Germany. ^[5]

医学主题词动物(Animals);抗体, 双特异性(Antibodies, Bispecific);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);T淋巴细胞(T-Lymphocytes)

DOI 10.1158/1535-7163.MCT-20-0269

PMID 33298591

发布时间 2021-10-19

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准确一般字义偏差语意偏离译文作用小提交