A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes.

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第一作者： Wenkun,Dou

第一单位： Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada.

作者： Wenkun,Dou ^[1] ; Li,Wang ^[2] ; Manpreet,Malhi ^[3] ; Haijiao,Liu ^[4] ; Qili,Zhao ^[1] ; Julia,Plakhotnik ^[3] ; Zhensong,Xu ^[1] ; Zongjie,Huang ^[1] ; Craig A,Simmons ^[5] ; Jason T,Maynes ^[6] ; Yu,Sun ^[7]

作者单位： Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada. ^[1] Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada; School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China. ^[2] Program in Molecular Medicine, Hospital for Sick Children, Toronto, M5G 1X8, Canada; Department of Biochemistry, University of Toronto, Toronto, M5S 1A8, Canada. ^[3] Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, M5S 3G9, Canada. ^[4] Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, M5S 3G9, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, M5G 1M1, Canada. Electronic address: c.simmons@utoronto.ca. ^[5] Program in Molecular Medicine, Hospital for Sick Children, Toronto, M5G 1X8, Canada; Department of Biochemistry, University of Toronto, Toronto, M5S 1A8, Canada; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, M5G 1X8, Canada. Electronic address: jason.maynes@sickkids.ca. ^[6] Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, M5S 3G8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, M5S 3G9, Canada; Department of Electrical and Computer Engineering, University of Toronto, M5S 3G4, Canada; Department of Computer Science, University of Toronto, M5T 3A1, Canada. Electronic address: yu.sun@utoronto.ca. ^[7]

关键词 Contractile stress Maturation Mechanical stimulation Microdevice array iPSC-CMs

主题词生物传感技术(Biosensing Techniques);细胞分化(Cell Differentiation);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);肌细胞, 心脏(Myocytes, Cardiac);蛋白质组学(Proteomics);肌节(Sarcomeres)

DOI 10.1016/j.bios.2020.112875

PMID 33303322

发布时间 2021-05-14

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