Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations.

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作者： Károly,Kovács ^[1] ; Zoltán,Farkas ^[2] ; Djordje,Bajić ^[2] ; Dorottya,Kalapis ^[2] ; Andreea,Daraba ^[3] ; Karola,Almási ^[4] ; Bálint,Kintses ^[5] ; Zoltán,Bódi ^[1] ; Richard A,Notebaart ^[2] ; Juan F,Poyatos ^[2] ; Patrick,Kemmeren ^[2] ; Frank C P,Holstege ^[2] ; Csaba,Pál ^[6] ; Balázs,Papp ^[7]

作者单位： HCEMM-BRC Metabolic Systems Biology Lab, Szeged, Hungary. ^[1] Biological Research Centre, Synthetic and Systems Biology Unit, Institute of Biochemistry, Szeged, Hungary. ^[2] Logic of Genomic Systems Laboratory, Department of Systems Biology, CNB-CSIC, Madrid, Spain. ^[3] Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT. ^[4] Microbial Sciences Institute, Yale University West Campus, West Haven, CT. ^[5] HCEMM-BRC Translational Microbiology Lab, Szeged, Hungary. ^[6] Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary. ^[7] Food Microbiology, Wageningen University & Research, Wageningen, The Netherlands. ^[8] Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. ^[9]

关键词 fitness effect of mutations gene deletion gene expression regulation genotype–phenotype map

主题词基因缺失(Gene Deletion);基因表达调控, 真菌(Gene Expression Regulation, Fungal);酿酒酵母菌(Saccharomyces cerevisiae)

DOI 10.1093/molbev/msaa280

PMID 33306797

发布时间 2024-03-31

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