Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.

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第一作者： Koen,van Wijk

第一单位： Department of Functional Genomics, Yamagata University School of Medicine, Japan; Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Japan.

作者： Koen,van Wijk ^[1] ; Takeru,Akabane ^[2] ; Tomohiro,Kimura ^[1] ; Shinichi,Saitoh ^[1] ; Satoshi,Okano ^[1] ; Vincent P,Kelly ^[3] ; Michiaki,Takagi ^[4] ; Ken,Kodama ^[5] ; Kiwamu,Takahashi ^[6] ; Tohru,Tanaka ^[6] ; Motowo,Nakajima ^[6] ; Osamu,Nakajima ^[7]

作者单位： Department of Functional Genomics, Yamagata University School of Medicine, Japan; Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Japan. ^[1] Department of Functional Genomics, Yamagata University School of Medicine, Japan; Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Japan; Department of Orthopedics, Yamagata University School of Medicine, Japan. ^[2] School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. ^[3] Department of Orthopedics, Yamagata University School of Medicine, Japan. ^[4] Neopharma Japan Co., Ltd., Japan. ^[5] SBI Pharmaceuticals Co., Ltd., Japan. ^[6] Department of Functional Genomics, Yamagata University School of Medicine, Japan; Research Center for Molecular Genetics, Institute for Promotion of Medical Science Research, Yamagata University Faculty of Medicine, Japan. Electronic address: nakajima@med.id.yamagata-u.ac.jp. ^[7]

关键词 5-Aminolevulinate synthase 1 (ALAS1)5-Aminolevulinic acid (ALA)Aging Free heme Liver Skeletal muscle