Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8<sup>+</sup> T cells in autoimmunity and cancer.

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作者： Jared,Liu ^[1] ; Hsin-Wen,Chang ^[1] ; Zhi-Ming,Huang ^[1] ; Mio,Nakamura ^[2] ; Sahil,Sekhon ^[3] ; Richard,Ahn ^[4] ; Priscila,Munoz-Sandoval ^[1] ; Shrishti,Bhattarai ^[1] ; Kristen M,Beck ^[5] ; Isabelle M,Sanchez ^[6] ; Eric,Yang ^[1] ; Mariela,Pauli ^[1] ; Sarah T,Arron ^[1] ; Wai-Ping,Fung-Leung ^[7] ; Ernesto,Munoz ^[7] ; Xuejun,Liu ^[7] ; Tina,Bhutani ^[1] ; Jeffrey,North ^[1] ; Anne M,Fourie ^[7] ; Michael D,Rosenblum ^[1] ; Wilson,Liao ^[8]

作者单位： Department of Dermatology, University of California San Francisco, San Francisco, Calif. ^[1] Department of Dermatology, University of Michigan, Ann Arbor, Mich. ^[2] Department of Dermatology, Howard University, Washington, DC. ^[3] Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, Calif. ^[4] Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Tex. ^[5] Department of Dermatology, University of Illinois at Chicago, Chicago, Ill. ^[6] Janssen Research & Development, LLC, La Jolla, Calif. ^[7] Department of Dermatology, University of California San Francisco, San Francisco, Calif. Electronic address: wilson.liao@ucsf.edu. ^[8]

关键词 CD8(+) T cell Single-cell RNA sequencing Smart-seq2 T-cell exhaustion melanoma psoriasis