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首页> Cell calcium> T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.

T lymphocytes from malignant hyperthermia-susceptible mice display aberrations in intracellular calcium signaling and mitochondrial function.

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作者： Lukun,Yang ^[1] ; Elena N,Dedkova ^[2] ; Paul D,Allen ^[3] ; M Saleet,Jafri ^[4] ; Alla F,Fomina ^[5]

作者单位： Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, 95616, USA; Department of Anesthesiology, the 5th Affiliated Hospital of SUN YAT-SEN University, Zhuhai, 519000, China. Electronic address: yanglk@mail.sysu.edu.cn. ^[1] Department of Molecular Biosciences, University of California, Davis, Davis, CA, 95616, USA. Electronic address: ededkova@ucdavis.edu. ^[2] Department of Molecular Biosciences, University of California, Davis, Davis, CA, 95616, USA; MH Unit, St. James's University Hospital, University of Leeds, Leeds, LS9 7TF, United Kingdom. Electronic address: p.d.allen@leeds.ac.uk. ^[3] School of Systems Biology, George Mason University, Fairfax, VA, 22030, USA. Electronic address: sjafri@gmu.edu. ^[4] Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA, 95616, USA. Electronic address: affomina@ucdavis.edu. ^[5]

关键词 Dantrolene sodium Intracellular Ca(2+)Mitochondrial potential RYR1-p.R163C knock-in mice Ryanodine receptor T lymphocytes

主题词动物(Animals);钙(Calcium);钙信号(Calcium Signaling);细胞增殖(Cell Proliferation);基因型(Genotype);细胞内间隙(Intracellular Space);淋巴细胞活化(Lymphocyte Activation);恶性高热(Malignant Hyperthermia);膜电位, 线粒体(Membrane Potential, Mitochondrial);小鼠(Mice);线粒体(Mitochondria);突变蛋白质类(Mutant Proteins);T淋巴细胞(T-Lymphocytes);毒胡萝卜内酯(Thapsigargin)

DOI 10.1016/j.ceca.2020.102325

PMID 33310301

发布时间 2022-02-18

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