首页> Protein science : a publication of the Protein Society> Revisiting the phosphotyrosine binding pocket of Fyn SH2 domain led to the identification of novel SH2 superbinders.

Revisiting the phosphotyrosine binding pocket of Fyn SH2 domain led to the identification of novel SH2 superbinders.

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第一作者： Shuhao,Li

第一单位： College of Life Sciences, Qingdao University, Qingdao, China.;School of Basic Medicine, Qingdao University, Qingdao, China.;Department of Antibody Engineering, Shanghai Asia United Antibody Medical Co., Ltd, Shanghai, China.

作者： Shuhao,Li ^[1] ; Yang,Zou ^[2] ; Dongping,Zhao ^[3] ; Yuqing,Yin ^[4] ; Jingyi,Song ^[2] ; Ningning,He ^[2] ; Huadong,Liu ^[5] ; Dongmeng,Qian ^[6] ; Lei,Li ^[7] ; Haiming,Huang ^[4]

作者单位： College of Life Sciences, Qingdao University, Qingdao, China.;School of Basic Medicine, Qingdao University, Qingdao, China.;Department of Antibody Engineering, Shanghai Asia United Antibody Medical Co., Ltd, Shanghai, China. ^[1] School of Basic Medicine, Qingdao University, Qingdao, China. ^[2] School of Basic Medicine, Qingdao University, Qingdao, China.;Department of Antibody Engineering, Shanghai Asia United Antibody Medical Co., Ltd, Shanghai, China. ^[3] Department of Antibody Engineering, Shanghai Asia United Antibody Medical Co., Ltd, Shanghai, China. ^[4] Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China. ^[5] College of Life Sciences, Qingdao University, Qingdao, China.;School of Basic Medicine, Qingdao University, Qingdao, China. ^[6] School of Basic Medicine, Qingdao University, Qingdao, China.;The Cancer Institute, Qingdao University, Qingdao, China. ^[7]

关键词 SH2 superbinder directed evolution phage display phage displayed library construction and selection protein-peptide interaction