A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase.

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第一作者： Xuejie,Chen

第一单位： Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

作者： Xuejie,Chen ^[1] ; Yizhou,Liu ^[2] ; Natsuko,Furukawa ^[3] ; Da-Yun,Jin ^[1] ; G,Paul Savage ^[4] ; Darrel W,Stafford ^[1] ; Yoshitomo,Suhara ^[3] ; Craig M,Williams ^[2] ; Jian-Ke,Tie ^[1]

作者单位： Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[1] School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia. ^[2] Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama, Japan. ^[3] CSIRO Manufacturing, Ian Wark Laboratory, Melbourne, VIC, Australia. ^[4]

关键词 coagulation factors carboxylation cyclooctatetraene oral anticoagulant vitamin K antagonist vitamin K epoxide reductase

主题词动物(Animals);抗凝药(Anticoagulants);血液凝固(Blood Coagulation);维生素K(Vitamin K);维生素K1(Vitamin K 1);华法林(Warfarin)

DOI 10.1111/jth.15209

PMID 33314621

发布时间 2023-08-29

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准确一般字义偏差语意偏离译文作用小提交