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Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis.

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第一作者: Alex,Claveria-Cabello
第一单位: Program of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.
作者单位: Program of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain. [1] Program of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.;National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Carlos III Health Institute), 28029 Madrid, Spain. [2] Program of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.;IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain. [3] IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.;Department of Gastroenterology and Hepatology, Navarra University Hospital Complex, 31008 Pamplona, Spain. [4] National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Carlos III Health Institute), 28029 Madrid, Spain.;Liver Disease Laboratory, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, 48160 Derio, Spain. [5] National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Carlos III Health Institute), 28029 Madrid, Spain.;Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, 20014 San Sebastian, Spain.;IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain. [6] National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Carlos III Health Institute), 28029 Madrid, Spain.;IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.;Hepatology Unit, Department of Internal Medicine, University of Navarra Clinic, 31008 Pamplona, Spain. [7] Institute for Liver and Digestive Health, University College London, London NW3 2PF, UK. [8] Program of Molecular Therapeutics, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain. [9] National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Carlos III Health Institute), 28029 Madrid, Spain.;Experimental Hepatology and Drug Targeting (HEVEPHARM), University of Salamanca, Biomedical Research Institute of Salamanca (IBSAL), 37007 Salamanca, Spain. [10] Program of Hepatology, Center for Applied Medical Research (CIMA), University of Navarra, 31008 Pamplona, Spain.;National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Carlos III Health Institute), 28029 Madrid, Spain.;IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain. [11]
DOI 10.3390/cancers12123748
PMID 33322158
发布时间 2020-12-29
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