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首页> Molecules (Basel, Switzerland)> A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β.

A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β.

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作者： Satheesh,Gujarathi ^[1] ; Maroof Khan,Zafar ^[2] ; Xingui,Liu ^[1] ; Robert L,Eoff ^[2] ; Guangrong,Zheng ^[3]

作者单位： Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ^[1] Department of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ^[2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.;Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA. ^[3]

关键词 DNA polymerase β garcinoic acid semi-synthesis structure-activity-relationship δ-tocotrienol

主题词苯吡喃类(Benzopyrans);生物制品(Biological Products);DNA聚合酶β(DNA Polymerase beta);药物设计(Drug Design);酶抑制剂(Enzyme Inhibitors);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);酚(Phenol);构效关系(Structure-Activity Relationship);温度(Temperature);维生素E(Vitamin E)

DOI 10.3390/molecules25245847

PMID 33322249

发布时间 2024-09-23

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Molecules (Basel, Switzerland)

Molecules (Basel, Switzerland)

2020年25卷24期

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