<i>STK11</i>/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.-论文-万方医学网

第一作者： Piyada,Sitthideatphaiboon

第一单位： Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

作者： Piyada,Sitthideatphaiboon ^[1] ; Ana,Galan-Cobo ^[2] ; Marcelo V,Negrao ^[1] ; Xiao,Qu ^[1] ; Alissa,Poteete ^[1] ; Fahao,Zhang ^[3] ; Diane D,Liu ^[1] ; Whitney E,Lewis ^[1] ; Haley N,Kemp ^[4] ; Jeff,Lewis ^[5] ; Waree,Rinsurongkawong ^[1] ; Uma,Giri ^[4] ; J Jack,Lee ^[4] ; Jianjun,Zhang ^[1] ; Jack A,Roth ^[4] ; Stephen,Swisher ^[1] ; John V,Heymach ^[6]

作者单位： Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. ^[1] Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Chulalongkorn University/King Chulalongkorn Memorial Hospital, Bangkok, Thailand. ^[2] Institute of Oncology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, P.R. China. ^[3] Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas. ^[4] Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, Texas. ^[5] Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. ^[6] Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. jheymach@mdanderson.org. ^[7]

主题词动物(Animals);细胞凋亡(Apoptosis);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞增殖(Cell Proliferation);女(雌)性(Female);随访研究(Follow-Up Studies);γ射线(Gamma Rays);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);谷氨酰胺酶(Glutaminase);人类(Humans);肺肿瘤(Lung Neoplasms);男(雄)性(Male);小鼠(Mice);小鼠, 裸(Mice, Nude);中年人(Middle Aged);突变(Mutation);NF-E2相关因子2(NF-E2-Related Factor 2);预后(Prognosis);辐射耐受性(Radiation Tolerance);放射疗法(Radiotherapy);回顾性研究(Retrospective Studies);存活率(Survival Rate);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/1078-0432.CCR-20-2859

PMID 33323404

发布时间 2022-03-07

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<i>STK11</i>/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.

Clinical cancer research

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Clinical cancer research

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<i>STK11</i>/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.

Clinical cancer research

相似文献

Clinical cancer research

相关期刊

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