Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of <i>N</i>-Methyl-d-aspartate Receptors.

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第一作者： Katie L,Strong

第一单位： Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.

作者： Katie L,Strong ^[1] ; Matthew P,Epplin ^[2] ; Kevin K,Ogden ^[2] ; Pieter B,Burger ^[1] ; Thomas M,Kaiser ^[2] ; Timothy J,Wilding ^[2] ; Hiro,Kusumoto ^[3] ; Chad R,Camp ^[1] ; Gil,Shaulsky ^[1] ; Subhrajit,Bhattacharya ^[1] ; Riley E,Perszyk ^[4] ; David S,Menaldino ^[1] ; Miranda J,McDaniel ^[2] ; Jing,Zhang ^[1] ; Phuong,Le ^[1] ; Tue G,Banke ^[1] ; Kasper B,Hansen ^[1] ; James E,Huettner ^[1] ; Dennis C,Liotta ^[5] ; Stephen F,Traynelis ^[3]

作者单位： Department of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States. ^[1] Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States. ^[2] Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63110, United States. ^[3] Department of Drug Discovery and Development, Auburn University, Auburn, Alabama 36849, United States. ^[4] Center for Biomolecular Structure and Dynamics, Center for Structural and Functional Neuroscience, Division for Biological Sciences, University of Montana, 32 Campus Drive, Missoula, Montana 59812, United States. ^[5]

关键词 EPSC Electrophysiology molecular dynamics positive allosteric modulator

主题词别构调节(Allosteric Regulation);模型, 分子(Models, Molecular);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);突触传递(Synaptic Transmission)

DOI 10.1021/acschemneuro.0c00561

PMID 33326224

发布时间 2022-01-07

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