Identification of Phenazine-Based MEMO1 Small-Molecule Inhibitors: Virtual Screening, Fluorescence Polarization Validation, and Inhibition of Breast Cancer Migration.

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作者： Courtney L,Labrecque ^[1] ; Cassidy N,Hilton ^[1] ; Justin,Airas ^[1] ; Alexis,Blake ^[1] ; Kristen J,Rubenstein ^[1] ; Carol A,Parish ^[1] ; Julie A,Pollock ^[1]

作者单位： Department of Chemistry, University of Richmond, 138 UR Drive, Richmond, VA 23173, USA. ^[1]

关键词 MEMO1 breast cancer migration phenazine protein-protein interactions

主题词抗肿瘤药(Antineoplastic Agents);乳腺肿瘤(Breast Neoplasms);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物评价, 临床前(Drug Evaluation, Preclinical);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);女(雌)性(Female);荧光偏振(Fluorescence Polarization);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);分子动力学模拟(Molecular Dynamics Simulation);分子结构(Molecular Structure);吩嗪类(Phenazines);小分子化合物库(Small Molecule Libraries);构效关系(Structure-Activity Relationship);肿瘤细胞, 培养的(Tumor Cells, Cultured)

DOI 10.1002/cmdc.202000797

PMID 33332774

发布时间 2021-12-28

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ChemMedChem

2021年16卷7期

1163-1171页

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Identification of Phenazine-Based MEMO1 Small-Molecule Inhibitors: Virtual Screening, Fluorescence Polarization Validation, and Inhibition of Breast Cancer Migration.

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Identification of Phenazine-Based MEMO1 Small-Molecule Inhibitors: Virtual Screening, Fluorescence Polarization Validation, and Inhibition of Breast Cancer Migration.

ChemMedChem

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