Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[<i>g</i>]quinazoline Derivatives (In Vitro).

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作者： Hatem A,Abuelizz ^[1] ; Mohamed,Marzouk ^[2] ; Ahmed H,Bakheit ^[3] ; Hanem M,Awad ^[2] ; Maha M,Soltan ^[4] ; Ahmed M,Naglah ^[5] ; Rashad,Al-Salahi ^[1]

作者单位： Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ^[1] Department of Tanning Materials and Leather Technology, National Research Centre, 33 El-Bohouth St. (Former El-Tahrir St.), Dokki, Cairo 12622, Egypt. ^[2] Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.;Department of Chemistry, Faculty of Science and Technology, El-Neelain University, P.O. Box 12702, Khartoum 11121, Sudan. ^[3] Biology Unit, Central Laboratory for Pharmaceutical and Drug Industries Research Division, Chemistry of Medicinal Plants Department, National Research Centre, El Bohouth St. 33, Dokki, Cairo 12622, Egypt. ^[4] Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.;Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 33 El-Bohouth St. (Former El-Tahrir St.), Dokki, Cairo 12622, Egypt. ^[5]

关键词 HepG2 MCF-7 MTT assay QSAR VEGFR-2 apoptosis benzoquinazolines docking study