Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions.

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作者： Liselot M,Mus ^[1] ; Stéphane,Van Haver ^[1] ; Mina,Popovic ^[2] ; Wim,Trypsteen ^[1] ; Steve,Lefever ^[1] ; Nadja,Zeltner ^[3] ; Yudelca,Ogando ^[4] ; Eva Z,Jacobs ^[5] ; Geertrui,Denecker ^[1] ; Ellen,Sanders ^[1] ; Christophe,Van Neste ^[1] ; Suzanne,Vanhauwaert ^[1] ; Bieke,Decaesteker ^[1] ; Dieter,Deforce ^[6] ; Filip,Van Nieuwerburgh ^[6] ; Pieter,Mestdagh ^[1] ; Jo,Vandesompele ^[1] ; Björn,Menten ^[5] ; Katleen,De Preter ^[1] ; Lorenz,Studer ^[7] ; Björn,Heindryckx ^[2] ; Kaat,Durinck ^[1] ; Stephen,Roberts ^[4] ; Frank,Speleman ^[1]

作者单位： Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.;Ghent University, Cancer Research Institute Ghent (CRIG), Ghent, Belgium. ^[1] Ghent-Fertility and Stem Cell Team (G-FaST), Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium. ^[2] Center for Molecular Medicine, Department of Biochemistry & Molecular Biology and Department of Cellular Biology, University of Georgia, Athens, Georgia, USA. ^[3] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, USA. ^[4] Department of Biomolecular Medicine, Ghent University, Ghent, Belgium. ^[5] Ghent University, Cancer Research Institute Ghent (CRIG), Ghent, Belgium.;Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium. ^[6] The Center for Stem Cell Biology, Sloan Kettering Institute, New York, USA.;Developmental Biology Program, Sloan Kettering Institute, New York, USA. ^[7]

关键词 copy number variations hESC replicative stress