DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.

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第一作者： Changzheng,Lu

第一单位： Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

作者： Changzheng,Lu ^[1] ; Junhong,Guan ^[2] ; Steve,Lu ^[3] ; Qihuang,Jin ^[2] ; Benoit,Rousseau ^[4] ; Tianshi,Lu ^[5] ; Dennis,Stephens ^[4] ; Hongyi,Zhang ^[6] ; Jiankun,Zhu ^[1] ; Mingming,Yang ^[2] ; Zhenhua,Ren ^[1] ; Yong,Liang ^[1] ; Zhida,Liu ^[1] ; Chuanhui,Han ^[1] ; Longchao,Liu ^[1] ; Xuezhi,Cao ^[1] ; Anli,Zhang ^[1] ; Jian,Qiao ^[1] ; Kimberly,Batten ^[7] ; Mingyi,Chen ^[1] ; Diego H,Castrillon ^[8] ; Tao,Wang ^[5] ; Bo,Li ^[6] ; Luis A,Diaz ^[4] ; Guo-Min,Li ^[9] ; Yang-Xin,Fu ^[10]

作者单位： Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA. ^[1] Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA. ^[2] Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA. ^[3] Department of Medicine, Division of Solid Tumors, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX 75390, USA. ^[5] Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX 75390, USA. ^[6] Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[7] Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX 75390, USA. ^[8] Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: guo-min.li@utsouthwestern.edu. ^[9] Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: yang-xin.fu@utsouthwestern.edu. ^[10]

关键词 DNA sensing MLH1 MSI STING T cell infiltration cGAS cancer checkpoint blockade cytosolic DNA mismatch repair