Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications.

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作者： Lara S,Costard ^[1] ; Domhnall C,Kelly ^[1] ; Rachael N,Power ^[2] ; Christopher,Hobbs ^[1] ; Sonia,Jaskaniec ^[3] ; Valeria,Nicolosi ^[4] ; Brenton L,Cavanagh ^[3] ; Caroline M,Curtin ^[4] ; Fergal J,O'Brien ^[3]

作者单位： Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), 123 St Stephen's Green, D02 YN77 Dublin, Ireland. ^[1] Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences Building, National University of Ireland, Galway (NUI, Galway), H91 TK33 Galway, Ireland. ^[2] Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and Trinity College Dublin (TCD), College Green, D02 PN40 Dublin, Ireland. ^[3] School of Chemistry and Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, College Green, D02 PN40 Dublin, Ireland. ^[4] Cellular and Molecular Imaging Core, RCSI, 123 St Stephen's Green, D02 YN77 Dublin, Ireland. ^[5] Trinity Centre for BioMedical Engineering, Trinity Biomedical Sciences Institute, TCD, College Green, D02 PN40 Dublin, Ireland. ^[6]

关键词 biomaterials drug delivery gene therapy layered double hydroxide microRNA nonviral vector plasmid DNA scaffold siRNA

DOI 10.3390/pharmaceutics12121219

PMID 33339452

发布时间 2020-12-29

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