Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.

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作者： Michael D,Weiss ^[1] ; Eric A,Macklin ^[2] ; Courtney E,McIlduff ^[3] ; Steve,Vucic ^[4] ; Brian J,Wainger ^[5] ; Matthew C,Kiernan ^[4] ; Stephen A,Goutman ^[6] ; Namita A,Goyal ^[7] ; Seward B,Rutkove ^[3] ; Shafeeq S,Ladha ^[8] ; I-Hweii Amy,Chen ^[9] ; Matthew B,Harms ^[10] ; Thomas H,Brannagan ^[10] ; David,Lacomis ^[11] ; Sasha,Zivkovic ^[11] ; Maxwell,Ma ^[1] ; Leo H,Wang ^[1] ; Zachary,Simmons ^[12] ; Michael H,Rivner ^[13] ; Jeremy M,Shefner ^[8] ; Merit E,Cudkowicz ^[5] ; Nazem,Atassi ^[5] ; Mexiletine-2 ALS Study Group

作者单位： Department of Neurology, University of Washington, Seattle, Washington, USA. ^[1] Department of Medicine, Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. ^[2] Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. ^[3] Department of Neurology, Royal Prince Alfred Hospital; and the Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. ^[4] Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. ^[5] Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA. ^[6] Department of Neurology, University of California, Irvine, California, USA. ^[7] Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA. ^[8] Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA. ^[9] Department of Neurology, Columbia University, New York, New York, USA. ^[10] Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. ^[11] Department of Neurology, Penn State University, Hershey, Pennsylvania, USA. ^[12] Department of Neurology, Augusta University, Augusta, Georgia, USA. ^[13]

关键词 amyotrophic lateral sclerosis axonal excitability outcome research randomized controlled clinical trial transcranial magnetic stimulation