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Novel DiOC<sub>3</sub> 96-well real-time efflux assay for discovery of NorA efflux pump inhibitors in Staphylococcus aureus.

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第一作者： Najoua,Elhidar

第一单位： Friedrich Loeffler Institute of Medical Microbiology, University of Medicine Greifswald, Germany; Laboratory of Microbial Biotechnologies, Agrosciences and Environment, Faculty of Sciences, Semlalia, Cadi Ayyad University, Marrakech, Morocco.

作者： Najoua,Elhidar ^[1] ; Ahmed,Nafis ^[2] ; André,Goehler ^[3] ; Abdelaziz,Abbad ^[2] ; Lahcen,Hassani ^[2] ; Nour-Eddine,Mezrioui ^[4] ; Jürgen A,Bohnert ^[3]

作者单位： Friedrich Loeffler Institute of Medical Microbiology, University of Medicine Greifswald, Germany; Laboratory of Microbial Biotechnologies, Agrosciences and Environment, Faculty of Sciences, Semlalia, Cadi Ayyad University, Marrakech, Morocco. ^[1] Laboratory of Microbial Biotechnologies, Agrosciences and Environment, Faculty of Sciences, Semlalia, Cadi Ayyad University, Marrakech, Morocco. ^[2] Friedrich Loeffler Institute of Medical Microbiology, University of Medicine Greifswald, Germany. ^[3] Laboratory of Microbial Biotechnologies, Agrosciences and Environment, Faculty of Sciences, Semlalia, Cadi Ayyad University, Marrakech, Morocco. Electronic address: mezrioui@uca.ac.ma. ^[4]

关键词 96-well plate DiOC(3)Efflux assay Multidrug resistance NorA efflux pump Staphylococcus aureus

医学主题词抗菌药(Anti-Bacterial Agents);细菌蛋白质类(Bacterial Proteins);药物发现(Drug Discovery);药物评价, 临床前(Drug Evaluation, Preclinical);多药耐药相关蛋白质类(Multidrug Resistance-Associated Proteins);葡萄球菌感染(Staphylococcal Infections);金黄色葡萄球菌(Staphylococcus aureus)

DOI 10.1016/j.mimet.2020.106128

PMID 33347918

发布时间 2021-09-27

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