Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.

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作者： Steven T,Laing ^[1] ; Nardos,Tassew ^[1] ; Devin,Tesar ^[2] ; Yue,Wang ^[2] ; Susan R,Crowell ^[3] ; Julia,Gray ^[4] ; Mandy,Kwong ^[4] ; Kelly M,Loyet ^[4] ; Roxanne,Andaya ^[1] ; Aija,Kusi ^[1] ; Robert F,Kelley ^[2]

作者单位： Department of Safety Assessment, 7412Genentech Inc., South San Francisco, CA, USA. ^[1] Department of Pharmaceutical Development, 7412Genentech Inc., South San Francisco, CA, USA. ^[2] Department of Preclinical and Translational Pharmacokinetics & Pharmacodynamics, 7412Genentech Inc., South San Francisco, CA, USA. ^[3] Department of Biochemical and Cellular Pharmacology, 7412Genentech Inc., South San Francisco, CA, USA. ^[4]

关键词 drug development hyaluronic acid-binding proteins immunohistochemistry long-acting delivery mechanisms of toxicity ocular toxicity retina

主题词动物(Animals);神经胶质原纤维酸性蛋白质(Glial Fibrillary Acidic Protein);玻璃体内注射(Intravitreal Injections);兔(Rabbits);视网膜(Retina);视网膜变性(Retinal Degeneration)

DOI 10.1177/0192623320969124

PMID 33349160

发布时间 2022-05-31

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