SIRT1 inhibitors mitigate radiation-induced GI syndrome by enhancing intestinal-stem-cell survival.

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作者： Guoxiang,Fu ^[1] ; Shengzhi,Chen ^[1] ; Liping,Liang ^[2] ; Xiaomeng,Li ^[1] ; Peiyuan,Tang ^[1] ; Xinxin,Rao ^[1] ; Mengxue,Pan ^[1] ; Xiaoya,Xu ^[1] ; Yuanchuang,Li ^[3] ; Ye,Yao ^[2] ; Yi,Zhou ^[1] ; Jun,Gao ^[4] ; Shaobo,Mo ^[5] ; Sanjun,Cai ^[5] ; Junjie,Peng ^[5] ; Zhen,Zhang ^[2] ; Hans,Clevers ^[6] ; Jianjun,Gao ^[1] ; Guoqiang,Hua ^[7]

作者单位： Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, China. ^[1] Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China. ^[2] Research and Early Development, D1Med Technology (Shanghai) Inc, Shanghai, 200235, China. ^[3] Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, Jiangsu, 211166, China. ^[4] Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. ^[5] Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT, Utrecht, the Netherlands. ^[6] Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, China; Cancer Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, China. Electronic address: guoqianghua@fudan.edu.cn. ^[7]

关键词 GI syndrome Intestinal stem cells Mitigation Radiation SIRT1