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首页> Behavioural brain research> Astroglial glutamate transporter 1 and glutamine synthetase of the nucleus accumbens are involved in the antidepressant-like effects of allopregnanolone in learned helplessness rats.

Astroglial glutamate transporter 1 and glutamine synthetase of the nucleus accumbens are involved in the antidepressant-like effects of allopregnanolone in learned helplessness rats.

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作者： Masahito,Nangaku ^[1] ; Kouhei,Yoshino ^[1] ; Yasunori,Oda ^[2] ; Makoto,Kimura ^[1] ; Hiroshi,Kimura ^[1] ; Yuki,Hirose ^[1] ; Yukihiko,Shirayama ^[3] ; Masaomi,Iyo ^[1]

作者单位： Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana Chuou-ku, Chiba, Chiba, 260-8670, Japan. ^[1] Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana Chuou-ku, Chiba, Chiba, 260-8670, Japan. Electronic address: odayasunori@chiba-u.jp. ^[2] Department of Psychiatry, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 290-0111, Japan. ^[3]

关键词 Allopregnanolone (ALLO)Depression Glutamate transporter-1 (GLT-1)Glutamine synthetase (GS)Learned helplessness (LH)Nucleus accumbens (NAc)

主题词动物(Animals);抗抑郁药(Antidepressive Agents);行为, 动物(Behavior, Animal);CA1区, 海马(CA1 Region, Hippocampal);抑郁(Depression);疾病模型, 动物(Disease Models, Animal);兴奋性氨基酸转运子2(Excitatory Amino Acid Transporter 2);谷氨酰胺连接酶(Glutamate-Ammonia Ligase);无助状态, 学习(Helplessness, Learned);男(雄)性(Male);伏核(Nucleus Accumbens);孕烷诺龙(Pregnanolone);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)

DOI 10.1016/j.bbr.2020.113092

PMID 33359844

发布时间 2021-11-15

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Behavioural brain research

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