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首页> Proceedings of the National Academy of Sciences of the United States of America> Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling.

Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling.

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第一作者： Yuxuan,Guo

第一单位： Department of Cardiology, Boston Children's Hospital, Boston, MA 02115; guo@bjmu.edu.cn William.Pu@cardio.chboston.org.

作者： Yuxuan,Guo ^[1] ; Yangpo,Cao ^[2] ; Blake D,Jardin ^[2] ; Isha,Sethi ^[2] ; Qing,Ma ^[3] ; Behzad,Moghadaszadeh ^[2] ; Emily C,Troiano ^[4] ; Neil,Mazumdar ^[4] ; Michael A,Trembley ^[2] ; Eric M,Small ^[2] ; Guo-Cheng,Yuan ^[5] ; Alan H,Beggs ^[3] ; William T,Pu ^[4]

作者单位： Department of Cardiology, Boston Children's Hospital, Boston, MA 02115; guo@bjmu.edu.cn William.Pu@cardio.chboston.org. ^[1] Department of Cardiology, Boston Children's Hospital, Boston, MA 02115. ^[2] Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215. ^[3] Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115. ^[4] Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642. ^[5] Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138. ^[6]

关键词 MRTF SRF actinin 2 cardiomyocyte maturation cardiomyopathy

主题词辅肌动蛋白(Actinin);动物(Animals);细胞核(Cell Nucleus);细胞骨架(Cytoskeleton);基因表达调控(Gene Expression Regulation);小鼠(Mice);线粒体(Mitochondria);形态发生(Morphogenesis);突变(Mutation);肌细胞, 心脏(Myocytes, Cardiac);肌节(Sarcomeres);血清反应因子(Serum Response Factor);信号传导(Signal Transduction);反式激活因子类(Trans-Activators);转录因子(Transcription Factors)

DOI 10.1073/pnas.2008861118

PMID 33361330

发布时间 2022-01-29

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2021年118卷2期

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2021年118卷2期

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