m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance.

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第一作者： Tengfei,Zhou

第一单位： International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/Institute, The Second Military Medical University, Shanghai, China.

作者： Tengfei,Zhou ^[1] ; Shichao,Li ^[1] ; Daimin,Xiang ^[1] ; Junyu,Liu ^[1] ; Wen,Sun ^[1] ; Xiuliang,Cui ^[1] ; Beifang,Ning ^[2] ; Xiao,Li ^[3] ; Zhuo,Cheng ^[1] ; Weiqi,Jiang ^[1] ; Cheng,Zhang ^[1] ; Xijun,Liang ^[1] ; Liang,Li ^[1] ; Xin,Cheng ^[3] ; Liu,Hui ^[4] ; Hongyang,Wang ^[5] ; Jin,Ding ^[6]

作者单位： International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/Institute, The Second Military Medical University, Shanghai, China. ^[1] Department of Gastroenterology, Changzheng Hospital, The Second Military Medical University, Shanghai, China. ^[2] Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. ^[3] The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China. liuhuigg@hotmail.com. ^[4] International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/Institute, The Second Military Medical University, Shanghai, China. hywangk@vip.sina.com. ^[5] National Center for Liver Cancer, Shanghai, China. hywangk@vip.sina.com. ^[6] International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/Institute, The Second Military Medical University, Shanghai, China. dingjin1103@163.com. ^[7] National Center for Liver Cancer, Shanghai, China. dingjin1103@163.com. ^[8] Tongji University School of Medicine, Shanghai, China. dingjin1103@163.com. ^[9]

主题词动物(Animals);抗体, 嗜异性(Antibodies, Heterophile);癌, 肝细胞(Carcinoma, Hepatocellular);细胞去分化(Cell Dedifferentiation);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);肝细胞核因子3γ(Hepatocyte Nuclear Factor 3-gamma);人类(Humans);肝肿瘤(Liver Neoplasms);男(雄)性(Male);小鼠(Mice);肿瘤蛋白质类(Neoplasm Proteins);肿瘤移植(Neoplasm Transplantation);RNA加工, 转录后(RNA Processing, Post-Transcriptional);RNA, 信使(RNA, Messenger);RNA, 肿瘤(RNA, Neoplasm)

DOI 10.1038/s41392-020-00299-0

PMID 33361765

发布时间 2021-10-13

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Signal transduction and targeted therapy

2020年5卷1期

296页

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m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance.

Signal transduction and targeted therapy

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Signal transduction and targeted therapy

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m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance.

Signal transduction and targeted therapy

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Signal transduction and targeted therapy

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