Population Pharmacodynamic Modeling Using the Sigmoid E<sub>max</sub> Model: Influence of Inter-individual Variability on the Steepness of the Concentration-Effect Relationship. a Simulation Study.

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作者： Johannes H,Proost ^[1] ; Douglas J,Eleveld ^[2] ; Michel M R F,Struys ^[3]

作者单位： Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. j.h.proost@umcg.nl. ^[1] Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands. j.h.proost@umcg.nl. ^[2] Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. ^[3] Department of Anesthesia, Ghent University, Gent, Belgium. ^[4]

关键词 inter-individual variability pharmacokinetic-pharmacodynamic modeling sigmoid Emax model simulation

主题词计算机模拟(Computer Simulation);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);模型, 生物学(Models, Biological);概率(Probability)

DOI 10.1208/s12248-020-00549-7

PMID 33367961

发布时间 2021-09-27

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