Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Na<sub>v</sub> 1.2 expression.

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第一作者： Muriel,Eaton

第一单位： Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.

作者： Muriel,Eaton ^[1] ; Jingliang,Zhang ^[2] ; Zhixiong,Ma ^[1] ; Anthony C,Park ^[2] ; Emma,Lietzke ^[1] ; Chloé M,Romero ^[2] ; Yushuang,Liu ^[1] ; Emily R,Coleman ^[2] ; Xiaoling,Chen ^[1] ; Tiange,Xiao ^[2] ; Zhefu,Que ^[1] ; Shirong,Lai ^[2] ; Jiaxiang,Wu ^[1] ; Ji Hea,Lee ^[2] ; Sophia,Palant ^[1] ; Huynhvi P,Nguyen ^[2] ; Zhuo,Huang ^[1] ; William C,Skarnes ^[2] ; Wendy A,Koss ^[1] ; Yang,Yang ^[2]

作者单位： Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA. ^[1] Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, Indiana, USA. ^[2] Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China. ^[3] Department of Cellular Engineering, The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA. ^[4] Office of the Executive Vice President for Research and Partnerships, Purdue University, West Lafayette, Indiana, USA. ^[5]

关键词 Nav1.2 SCN2A gene behavior channelopathy gene-trap knockout genetic variants mouse model nesting neurodevelopmental disorder open field voltage-gated sodium channel

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);人类(Humans);小鼠, 基因敲除(Mice, Knockout);突变(Mutation);表型(Phenotype);小鼠(Mice)

DOI 10.1111/gbb.12725

PMID 33369088

发布时间 2024-02-26

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