Multiplex Single-Molecule Kinetics of Nanopore-Coupled Polymerases.

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第一作者： Mirkó,Palla

第一单位： Harvard Medical School, Department of Genetics, Boston, Massachusetts 02115, United States.;Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, United States.

作者： Mirkó,Palla ^[1] ; Sukanya,Punthambaker ^[1] ; Benjamin,Stranges ^[2] ; Frederic,Vigneault ^[3] ; Jeff,Nivala ^[2] ; Daniel,Wiegand ^[3] ; Aruna,Ayer ^[4] ; Timothy,Craig ^[4] ; Dmitriy,Gremyachinskiy ^[4] ; Helen,Franklin ^[4] ; Shaw,Sun ^[4] ; James,Pollard ^[4] ; Andrew,Trans ^[4] ; Cleoma,Arnold ^[4] ; Charles,Schwab ^[4] ; Colin,Mcgaw ^[4] ; Preethi,Sarvabhowman ^[4] ; Dhruti,Dalal ^[4] ; Eileen,Thai ^[4] ; Evan,Amato ^[4] ; Ilya,Lederman ^[4] ; Meng,Taing ^[4] ; Sara,Kelley ^[4] ; Adam,Qwan ^[4] ; Carl W,Fuller ^[5] ; Stefan,Roever ^[4] ; George M,Church ^[1]

作者单位： Harvard Medical School, Department of Genetics, Boston, Massachusetts 02115, United States.;Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, United States. ^[1] Harvard Medical School, Department of Genetics, Boston, Massachusetts 02115, United States. ^[2] Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, United States. ^[3] Roche Sequencing Solutions, Santa Clara, California 95050, United States. ^[4] Roche Sequencing Solutions, Santa Clara, California 95050, United States.;Columbia University, Center for Genome Technology and Biomolecular Engineering, Department of Chemical Engineering, New York, New York 10027, United States. ^[5]

关键词 kinetic characterization multiplex barcoding nanopore sequencing polymerase screening single-molecule detection

主题词 DNA(DNA);指导DNA的DNA聚合酶(DNA-Directed DNA Polymerase);动力学(Kinetics);纳米孔(Nanopores);序列分析, DNA(Sequence Analysis, DNA)

DOI 10.1021/acsnano.0c05226

PMID 33370106

发布时间 2022-12-21

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