Elevated EZH2 in ischemic heart disease epigenetically mediates suppression of Na<sub>V</sub>1.5 expression.

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作者： Limei,Zhao ^[1] ; Tao,You ^[1] ; Yan,Lu ^[1] ; Shin,Lin ^[2] ; Faqian,Li ^[3] ; Haodong,Xu ^[4]

作者单位： Department of Laboratory Medicine and Pathology, Center for Cardiovascular Biology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA. ^[1] Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195, USA. ^[2] Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. ^[3] Department of Laboratory Medicine and Pathology, Center for Cardiovascular Biology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address: xuh8@uw.edu. ^[4]

关键词 EZH2 H3K27me3 IHD Na(+) channel Na(V)1.5

主题词动物(Animals);表观基因组学(Epigenomics);基因表达调控(Gene Expression Regulation);组蛋白类(Histones);人类(Humans);小鼠(Mice);心肌缺血(Myocardial Ischemia);启动区, 遗传(Promoter Regions, Genetic)

DOI 10.1016/j.yjmcc.2020.12.012

PMID 33370552

发布时间 2022-04-02

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Journal of molecular and cellular cardiology

2021年153卷

95-103页

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Elevated EZH2 in ischemic heart disease epigenetically mediates suppression of Na<sub>V</sub>1.5 expression.

Journal of molecular and cellular cardiology

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Journal of molecular and cellular cardiology

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Elevated EZH2 in ischemic heart disease epigenetically mediates suppression of Na<sub>V</sub>1.5 expression.

Journal of molecular and cellular cardiology

相似文献

Journal of molecular and cellular cardiology

相关期刊

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