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Distinct developmental pathways from blood monocytes generate human lung macrophage diversity.

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第一作者： Elza,Evren

第一单位： Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, 141 52 Stockholm, Sweden.

作者： Elza,Evren ^[1] ; Emma,Ringqvist ^[1] ; Kumar Parijat,Tripathi ^[2] ; Natalie,Sleiers ^[1] ; Inés Có,Rives ^[1] ; Arlisa,Alisjahbana ^[1] ; Yu,Gao ^[1] ; Dhifaf,Sarhan ^[3] ; Tor,Halle ^[4] ; Chiara,Sorini ^[2] ; Rico,Lepzien ^[5] ; Nicole,Marquardt ^[1] ; Jakob,Michaëlsson ^[1] ; Anna,Smed-Sörensen ^[5] ; Johan,Botling ^[4] ; Mikael C I,Karlsson ^[3] ; Eduardo J,Villablanca ^[2] ; Tim,Willinger ^[6]

作者单位： Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, 141 52 Stockholm, Sweden. ^[1] Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden. ^[2] Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 64 Stockholm, Sweden. ^[3] Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden. ^[4] Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden. ^[5] Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, 141 52 Stockholm, Sweden. Electronic address: tim.willinger@ki.se. ^[6]

关键词 blood monocytes fate mapping human macrophages humanized mice intravascular macrophages lung ontogeny origin single-cell RNA sequencing