BRAF paradox breakers PLX8394, PLX7904 are more effective against BRAFV600Ε CRC cells compared with the BRAF inhibitor PLX4720 and shown by detailed pathway analysis.

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作者： Kassandra,Koumaki ^[1] ; Georgia,Kontogianni ^[1] ; Vivian,Kosmidou ^[1] ; Fani,Pahitsa ^[1] ; Eftichia,Kritsi ^[1] ; Maria,Zervou ^[1] ; Aristotelis,Chatziioannou ^[1] ; Vassilis L,Souliotis ^[1] ; Olga,Papadodima ^[1] ; Alexander,Pintzas ^[2]

作者单位： Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece. ^[1] Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece. Electronic address: apint@eie.gr. ^[2]

关键词 BRAF paradox breakers Bioinformatics Colorectal cancer Combinatorial treatments Mcl-1 inhibitors Notch modulators RNA-sequencing

主题词抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);结直肠肿瘤(Colorectal Neoplasms);杂环化合物, 2环(Heterocyclic Compounds, 2-Ring);人类(Humans);吲哚类(Indoles);MAP激酶信号系统(MAP Kinase Signaling System);点突变(Point Mutation);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf);磺胺类(Sulfonamides)

DOI 10.1016/j.bbadis.2020.166061

PMID 33385518

发布时间 2021-07-02

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Biochimica et biophysica acta. Molecular basis of disease

2021年1867卷4期

166061页

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BRAF paradox breakers PLX8394, PLX7904 are more effective against BRAFV600Ε CRC cells compared with the BRAF inhibitor PLX4720 and shown by detailed pathway analysis.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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BRAF paradox breakers PLX8394, PLX7904 are more effective against BRAFV600Ε CRC cells compared with the BRAF inhibitor PLX4720 and shown by detailed pathway analysis.

Biochimica et biophysica acta. Molecular basis of disease

相似文献

Biochimica et biophysica acta. Molecular basis of disease

相关期刊

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