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首页> Inflammopharmacology> Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation.

Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation.

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第一作者： Sree Lalitha,Bojja

第一单位： Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

作者： Sree Lalitha,Bojja ^[1] ; Bikash,Medhi ^[2] ; Shashi,Anand ^[3] ; Alka,Bhatia ^[1] ; Rupa,Joshi ^[4] ; Ranjana W,Minz ^[3]

作者单位： Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. ^[1] Department of Pharmacology, Manipal College of Pharmaceutical Sciences, MAHE, Manipal, Karnataka, 576104, India. ^[2] Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. ^[3] Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. ^[4] Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. rwminz.minz88@gmail.com. ^[5]

关键词 Epileptogenesis Inflammation Metformin Neurodegeneration Rapamycin Status epilepticus mTOR

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);细胞因子类(Cytokines);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);海马(Hippocampus);炎症(Inflammation);男(雄)性(Male);二甲双胍(Metformin);神经元(Neurons);神经保护药(Neuroprotective Agents);大鼠(Rats);大鼠, Wistar(Rats, Wistar);信号传导(Signal Transduction);癫痫持续状态(Status Epilepticus);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1007/s10787-020-00782-8

PMID 33386490

发布时间 2021-12-04

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Inflammopharmacology

Inflammopharmacology

2021年29卷1期

137-151页

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