Novel tankyrase inhibitors suppress TDP-43 aggregate formation.

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作者： Kunikazu,Tanji ^[1] ; Fumiaki,Mori ^[2] ; Fumiyuki,Shirai ^[3] ; Takehiro,Fukami ^[4] ; Hiroyuki,Seimiya ^[5] ; Jun,Utsumi ^[5] ; Akiyoshi,Kakita ^[6] ; Koichi,Wakabayashi ^[2]

作者单位： Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan. Electronic address: kunikazu@hirosaki-u.ac.jp. ^[1] Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan. ^[2] Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science, RIKEN Cluster for Industry Partnerships, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan; Program for Drug Discovery and Medical Technology Platforms, RIKEN Cluster for Industry Partnerships, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan. ^[3] Program for Drug Discovery and Medical Technology Platforms, RIKEN Cluster for Industry Partnerships, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan. ^[4] Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. ^[5] Department of Pathology, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan. ^[6]

关键词 Amyotrophic lateral sclerosis Frontotemporal lobar degeneration Poly(ADP-ribose)TDP-43 Tankyrase