Discovery of acquired molecular signature on immune checkpoint inhibitors in paired tumor tissues.

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作者： Shin Hye,Yoo ^[1] ; Jihui,Yun ^[2] ; Bhumsuk,Keam ^[3] ; Seung-Pyo,Hong ^[4] ; Chan-Young,Ock ^[5] ; Jaemoon,Koh ^[6] ; Sehui,Kim ^[3] ; Yoon Kyung,Jeon ^[4] ; Kyeong Cheon,Jung ^[1] ; Miso,Kim ^[7] ; Tae Min,Kim ^[7] ; Dong-Wan,Kim ^[7] ; Jong-Il,Kim ^[7] ; Dae Seog,Heo ^[1]

作者单位： Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea. ^[1] Department of Clinical Medical Sciences, Seoul National University College of Medicine, Seoul, Korea. ^[2] Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Korea. ^[3] Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea. ^[4] Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea. bhumsuk@snu.ac.kr. ^[5] Seoul National University Cancer Research Institute, Seoul, Korea. bhumsuk@snu.ac.kr. ^[6] Department of Pathology, Seoul National University Hospital, Seoul, Korea. ^[7] Seoul National University Cancer Research Institute, Seoul, Korea. ^[8] Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, Korea. ^[9]

关键词 Immunotherapy Programmed cell death 1 receptor Tumor escape Tumor microenvironment