A thermosensitive, reactive oxygen species-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration in rats by inhibiting the secretory autophagy pathway.

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作者： Qiangqiang,Zheng ^[1] ; Haotian,Shen ^[1] ; Zongrui,Tong ^[2] ; Linxiang,Cheng ^[1] ; Yuzi,Xu ^[3] ; Zhiyun,Feng ^[1] ; Shiyao,Liao ^[4] ; Xiaojian,Hu ^[1] ; Zongyou,Pan ^[5] ; Zhengwei,Mao ^[2] ; Yue,Wang ^[1]

作者单位： Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. ^[1] MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. ^[2] Department of Oral Implantology and Prosthodontics, The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, P.R. China. ^[3] Department of Orthopedic Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310003, China. ^[4] Spine lab, Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.;Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, And Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. ^[5]

关键词 MR409 ROS responsive carrier disc degeneration injectable hydrogel secretory autophagy