Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction.

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第一作者： S,Fu

第一单位： Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: s.fu@qmul.ac.uk.

作者： S,Fu ^[1] ; H,Meng ^[2] ; S,Inamdar ^[3] ; B,Das ^[4] ; H,Gupta ^[5] ; W,Wang ^[6] ; C L,Thompson ^[7] ; M M,Knight ^[8]

作者单位： Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: s.fu@qmul.ac.uk. ^[1] Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: Huan.meng@qmul.ac.uk. ^[2] Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: s.r.inamdar@qmul.ac.uk. ^[3] Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. ^[4] Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: h.gupta@qmul.ac.uk. ^[5] Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: Wen.wang@qmul.ac.uk. ^[6] Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: Clare.l.thompson@qmul.ac.uk. ^[7] Centre for Predictive In Vitro Models, School of Engineering and Materials Science, Queen Mary University of London, UK. Electronic address: m.m.knight@qmul.ac.uk. ^[8]

关键词 Cartilage Cilia Hypo-osmolarity IL-1β Mechanotransduction TRPV4